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{SECT 0 {EXCHG {PARA 256 "" 0 "" {TEXT -1 52 "Mathematical Model of Pe
thidine Flow Throughout Body" }}{PARA 0 "" 0 "" {TEXT -1 0 "" }}}
{EXCHG {PARA 0 "> " 0 "" {MPLTEXT 1 0 122 "clinical_data := [[0.5, 0.4
2], [1,0.29],[1.5,0.22],[2,0.18],[2.5,0.15],[3,0.125],[4,0.096],[6,0.0
6],[8,0.038],[10,0.024]]:" }}}{EXCHG {PARA 0 "> " 0 "" {MPLTEXT 1 0 0 
"" }}{PARA 0 "> " 0 "" {MPLTEXT 1 0 41 "unassign('x1','x2', 'k12', 'k2
1', 'k10');" }}}{EXCHG {PARA 0 "" 0 "" {TEXT -1 24 "Definition of Vari
ables:" }}{PARA 0 "" 0 "" {TEXT -1 0 "" }}{PARA 0 "" 0 "" {TEXT -1 55 
"x1 = the concentration of Pethidine in the Blood Plasma" }}{PARA 0 "
" 0 "" {TEXT -1 55 "x2 = the concentration of Pethidine in the Other O
rgans" }}{PARA 0 "" 0 "" {TEXT -1 0 "" }}}{EXCHG {PARA 0 "" 0 "" 
{TEXT -1 47 "Concentration of Pethidine in the blood stream." }}{PARA 
0 "> " 0 "" {MPLTEXT 1 0 54 "de1 := diff(x1(t),t) = (-(k10+k12)*x1(t))
+(k21*x2(t));" }}{PARA 11 "" 1 "" {XPPMATH 20 "6#>%$de1G/-%%diffG6$-%#
x1G6#%\"tGF,,&*&,&%$k10G\"\"\"%$k12GF1F1F)F1!\"\"*&%$k21GF1-%#x2GF+F1F
1" }}}{EXCHG {PARA 0 "" 0 "" {TEXT -1 47 "Concentration of Pethidine i
n the other organs." }}{PARA 0 "> " 0 "" {MPLTEXT 1 0 47 "de2 := diff(
x2(t),t) = (k12*x1(t))-(k21*x2(t));" }}{PARA 11 "" 1 "" {XPPMATH 20 "6
#>%$de2G/-%%diffG6$-%#x2G6#%\"tGF,,&*&%$k12G\"\"\"-%#x1GF+F0F0*&%$k21G
F0F)F0!\"\"" }}}{EXCHG {PARA 0 "" 0 "" {TEXT -1 73 "Solving the system
 of equations for both blood stream and other organs.  " }}{PARA 0 "> \+
" 0 "" {MPLTEXT 1 0 66 "sol := dsolve(\{de1, de2, x1(0) = .50, x2(0) =
 0\}, \{x1(t), x2(t)\}):" }}}{EXCHG {PARA 0 "> " 0 "" {MPLTEXT 1 0 16 
"solx1 := sol[2];" }}{PARA 12 "" 1 "" {XPPMATH 20 "6#>%&solx1G/-%#x1G6
#%\"tG,$*&,2*&*&)%$k12G\"\"#\"\"\"-%$expG6#*&,*F0#!\"\"F1*&#F2F1F2%$k2
1GF2F9*&#F2F1F2%$k10GF2F9*&#F2F1F2-%%sqrtG6#,.*$F/F2F2*(F1F2F0F2F<F2F2
*(F1F2F0F2F?F2F2*$)F<F1F2F2*(F1F2F?F2F<F2F9*$)F?F1F2F2F2F2F2F)F2F2F2*$
-FC6#FEF2F9F8*&**FAF2F0F2F3F2F<F2F2*$-FC6#FEF2F9F2*&#F2F1F2*&*(F0F2F3F
2F?F2F2*$-FC6#FEF2F9F2F9*(FAF2F0F2F3F2F2*&*(FAF2F/F2-F46#,$*&,*F0F2F<F
2F?F2*$FBF2F2F2F)F2F8F2F2*$-FC6#FEF2F9F2*&#F2F1F2*&*(F0F2FjnF2F<F2F2*$
-FC6#FEF2F9F2F9*&**FAF2F0F2FjnF2F?F2F2*$-FC6#FEF2F9F2*(FAF2F0F2FjnF2F2
F2F0F9FA" }}}{EXCHG {PARA 0 "> " 0 "" {MPLTEXT 1 0 16 "solx2 := sol[1]
;" }}{PARA 12 "" 1 "" {XPPMATH 20 "6#>%&solx2G/-%#x2G6#%\"tG,&*&*&%$k1
2G\"\"\"-%$expG6#*&,*F-#!\"\"\"\"#*&#F.F6F.%$k21GF.F5*&#F.F6F.%$k10GF.
F5*&#F.F6F.-%%sqrtG6#,.*$)F-F6F.F.*(F6F.F-F.F9F.F.*(F6F.F-F.F<F.F.*$)F
9F6F.F.*(F6F.F<F.F9F.F5*$)F<F6F.F.F.F.F.F)F.F.F.*$-F@6#FBF.F5F>*&#F.F6
F.*&*&F-F.-F06#,$*&,*F-F.F9F.F<F.*$F?F.F.F.F)F.F4F.F.*$-F@6#FBF.F5F.F5
" }}}{EXCHG {PARA 0 "" 0 "" {TEXT -1 105 "We now make the assumption t
hat k12 < k21 < k10 because the drug eventually must clear out of the \+
body.  " }}}{PARA 0 "" 0 "" {TEXT -1 0 "" }}{EXCHG {PARA 0 "" 0 "" 
{TEXT -1 67 "We assign k12, k21, and k10 with evenly spaced constants \+
and graph." }}{PARA 0 "" 0 "" {TEXT -1 0 "" }}{PARA 0 "> " 0 "" 
{MPLTEXT 1 0 74 "subn_value_3 := simplify(subs(\{k12 = 0.1, k21 = 0.20
, k10 = .35\}, solx1));" }}{PARA 0 "> " 0 "" {MPLTEXT 1 0 77 "subn_val
ue_3_2 := simplify(subs(\{k12 = 0.1, k21 = 0.20, k10 = 0.35\}, solx2))
;" }}{PARA 11 "" 1 "" {XPPMATH 20 "6#>%-subn_value_3G/-%#x1G6#%\"tG,&-
%$expG6#,$F)$!+\"RTDO\"!#5$\"+NbMV%)!#6*&$\"+[ambTF1\"\"\"-F,6#,$F)$!+
5'eu8&F1F8F8" }}{PARA 11 "" 1 "" {XPPMATH 20 "6#>%/subn_value_3_2G/-%#
x2G6#%\"tG,&-%$expG6#,$F)$!+\"RTDO\"!#5$\"+dB`C8F1*&$\"+dB`C8F1\"\"\"-
F,6#,$F)$!+5'eu8&F1F7!\"\"" }}}{EXCHG {PARA 0 "> " 0 "" {MPLTEXT 1 0 
158 "plot(\{rhs(subn_value_3), rhs(subn_value_3_2), clinical_data\}, t
=0..10, Concentration = 0..0.5, title = `Conc. vs. Time for k12 = 0.1,
 k21 = 0.2, k10 = 0.35`);" }}{PARA 13 "" 1 "" {GLPLOT2D 934 606 606 
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10 0 2 9 1 4 2 1.000000 45.000000 45.000000 0 1 "Clinical Data for Con
c. of Pethidine in Blood Plasma" "Conc. of Pethidine in Other Organs" 
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\"*" 1 2 0 1 10 0 2 9 1 4 2 1.000000 45.000000 45.000000 0 1 "Curve 1
" "Conc. of Pethidine in Other Organs" "Conc. of Pethidine in Blood Pl
asma" }}}}{PARA 0 "" 0 "" {TEXT -1 0 "" }}{EXCHG {PARA 0 "" 0 "" 
{TEXT -1 137 "Comparison of concentrations of pethidine in the bloodst
ream (x1) and the organs (x2) for constants k12 = 0.1, k21 = 0.2, and \+
k10 = 0.35." }}}{EXCHG {PARA 0 "" 0 "" {TEXT -1 0 "" }}{PARA 0 "> " 0 
"" {MPLTEXT 1 0 68 "subn1 := simplify(subs(\{k12 = 0.05, k21 = 0.2, k1
0 = 0.35\}, solx1));" }}{PARA 0 "> " 0 "" {MPLTEXT 1 0 68 "subn2 := si
mplify(subs(\{k12 = 0.05, k21 = 0.2, k10 = 0.35\}, solx2));" }}{PARA 
11 "" 1 "" {XPPMATH 20 "6#>%&subn1G/-%#x1G6#%\"tG,&-%$expG6#,$F)$!+Qky
&e\"!#5$\"+q/LAt!#6*&$\"+`pwnUF1\"\"\"-F,6#,$F)$!+iN@9WF1F8F8" }}
{PARA 11 "" 1 "" {XPPMATH 20 "6#>%&subn2G/-%#x2G6#%\"tG,&-%$expG6#,$F)
$!+Qky&e\"!#5$\"+lZ$)Q))!#6*&$\"+lZ$)Q))F4\"\"\"-F,6#,$F)$!+iN@9WF1F8!
\"\"" }}}{EXCHG {PARA 0 "> " 0 "" {MPLTEXT 1 0 166 "plot(\{clinical_da
ta, rhs(subn2), rhs(subn1)\}, t = 0..10, Concentration = 0..0.5, title
 = `Concentration of Pethidine vs. Time for k12 = 0.05, k21 = 0.2, k10
 = 0.35`);" }}{PARA 13 "" 1 "" {GLPLOT2D 884 571 571 {PLOTDATA 2 "6(-%
'CURVESG6$7X7$$\"\"!F)F(7$$\"3GLLL3x&)*3\"!#=$\"3%4sq`.0rj#!#?7$$\"3em
mm;arz@F-$\"3W@Wxg3;0^F07$$\"3v***\\7y%*z7$F-$\"31NQ--<'=7(F07$$\"3[LL
$e9ui2%F-$\"3H5%*3bWmA!*F07$$\"3z***\\(oMrU^F-$\"3r&=MCiPG5\"!#>7$$\"3
nmmm\"z_\"4iF-$\"3uZd\"p`E,H\"FE7$$\"3Unmmm6m#G(F-$\"3?v79r$HfY\"FE7$$
\"39ommT&phN)F-$\"3(e7g\"H/iH;FE7$$\"3A,+v=ddC%*F-$\"373%QH;I6y\"FE7$$
\"3KLLe*=)H\\5!#<$\"3^aU0mP&=#>FE7$$\"3smm\"z/3uC\"Fgn$\"3QudE*eNh:#FE
7$$\"3!****\\7LRDX\"Fgn$\"35-*poJ1_O#FE7$$\"3%om;zR'ok;Fgn$\"3sQ)3Mw.
\"\\DFE7$$\"33++D1J:w=Fgn$\"3t]'f1wJIq#FE7$$\"3oLLL3En$4#Fgn$\"3#[#GLE
y'R$GFE7$$\"3#pmmT!RE&G#Fgn$\"3w02uV#['GHFE7$$\"3D+++D.&4]#Fgn$\"3Cz[*
p<;X,$FE7$$\"3;+++vB_<FFgn$\"3Yd$HV#**)43$FE7$$\"33+++v'Hi#HFgn$\"3#*p
#\\\"y*)QGJFE7$$\"3&om;z*ev:JFgn$\"3!3y:Su)yeJFE7$$\"3_LLL347TLFgn$\"3
1*[JQu25=$FE7$$\"3nLLLLY.KNFgn$\"3!He;Cd*G*=$FE7$$\"33++D\"o7Tv$Fgn$\"
3C3v4*>*=)=$FE7$$\"3?LLL$Q*o]RFgn$\"3iASt&[\"pyJFE7$$\"3m++D\"=lj;%Fgn
$\"3u4-5s$*=gJFE7$$\"3S++vV&R<P%Fgn$\"3O'y&\\cXnNJFE7$$\"3CML$e9Ege%Fg
n$\"3OhCm'[aQ5$FE7$$\"3]LLeR\"3Gy%Fgn$\"3A$*3N(4_(pIFE7$$\"3emm;/T1&*
\\Fgn$\"3*GA9FcX%GIFE7$$\"3=nm\"zRQb@&Fgn$\"3E?45jbG\")HFE7$$\"3:++v=>
Y2aFgn$\"3G5,QNTBPHFE7$$\"3Znm;zXu9cFgn$\"3IElz3s,()GFE7$$\"34+++]y))G
eFgn$\"3#Hp,A8QF$GFE7$$\"3H++]i_QQgFgn$\"3;N-\"*3;rxFFE7$$\"3b++D\"y%3
TiFgn$\"3\"f#QnaD-BFFE7$$\"3+++]P![hY'Fgn$\"3Ap1vw=,hEFE7$$\"3iKLL$Qx$
omFgn$\"3)of:x&yV/EFE7$$\"3Y+++v.I%)oFgn$\"3WS/R1dUVDFE7$$\"3?mm\"zpe*
zqFgn$\"3'y(y8.R\"y[#FE7$$\"3;,++D\\'QH(Fgn$\"3d#GGEgtoU#FE7$$\"3%HL$e
9S8&\\(Fgn$\"3SBw#HNt&pBFE7$$\"3s++D1#=bq(Fgn$\"3Aa')pJO))4BFE7$$\"3\"
HLL$3s?6zFgn$\"3;<ZP()*p=D#FE7$$\"3a***\\7`Wl7)Fgn$\"3#pl#R9Jj\">#FE7$
$\"3enmmm*RRL)Fgn$\"3OtnT([6U8#FE7$$\"3%zmmTvJga)Fgn$\"3?+%4R[\">w?FE7
$$\"3]MLe9tOc()Fgn$\"3J9\"p1nP%>?FE7$$\"31,++]Qk\\*)Fgn$\"3aP3Ou!R!o>F
E7$$\"3![LL3dg6<*Fgn$\"3!\\:H(=)z+\">FE7$$\"3%ymmmw(Gp$*Fgn$\"3y_!\\<j
Y\"f=FE7$$\"3C++D\"oK0e*Fgn$\"3+;b;Ze#e!=FE7$$\"35,+v=5s#y*Fgn$\"3)Q4y
u([xb<FE7$$\"#5F)$\"3UDi_O(*3.<FE-%'COLOURG6&%$RGBG$F^\\l!\"\"F(F(-F$6
$7S7$F($\"3++++++++]F-7$F2$\"35I@63di$e%F-7$F<$\"3YT=$\\'oO^UF-7$FG$\"
3nf7wCQ@3RF-7$FQ$\"31:'[K8;Ef$F-7$Fen$\"3_hwQk+g0LF-7$F[o$\"3Ug33&*\\a
hIF-7$F`o$\"3'\\Y'z\"3)GHGF-7$Feo$\"35[dipS64EF-7$Fjo$\"3HstOvv:3CF-7$
F_p$\"3([BPRqL!>AF-7$Fdp$\"3Avj*\\zjf1#F-7$Fip$\"3&\\&H]Tp[2>F-7$F^q$
\"3%H,4Wp_=w\"F-7$Fcq$\"3GA\")zc*zJj\"F-7$Fhq$\"3ItgOoSUD:F-7$F]r$\"3*
G)zLavf29F-7$Fbr$\"3[<O+u%>eJ\"F-7$Fgr$\"3WS3bm2`<7F-7$F\\s$\"3=#[o&G6
]P6F-7$Fas$\"39\"Q\"o_Gec5F-7$Ffs$\"3O7A'fS!pc)*FE7$F[t$\"33@A05$p^<*F
E7$F`t$\"3WmFSU0\\(f)FE7$Fet$\"3h!*R;!zp<-)FE7$Fjt$\"3ycN)zS`9Z(FE7$F_
u$\"3iXKYp`nGqFE7$Fdu$\"3iUjR#fj_e'FE7$Fiu$\"3y4Tq7\"[?;'FE7$F^v$\"3/X
s2CkXzdFE7$Fcv$\"3ipX<s<WOaFE7$Fhv$\"3c5n2CEF%3&FE7$F]w$\"33'[o>+p9z%F
E7$Fbw$\"3dG8>fUZ,XFE7$Fgw$\"3CwQ\\.6GdUFE7$F\\x$\"3(=siIq/*3SFE7$Fax$
\"3EJwfZfa\"z$FE7$Ffx$\"3Q)=@84K*zNFE7$F[y$\"33u5z\"=RsQ$FE7$F`y$\"3q5
(f;3_$*>$FE7$Fey$\"3alHeE\"G2.$FE7$Fjy$\"3i.S(*3D\")pGFE7$F_z$\"3FV?rV
O%3s#FE7$Fdz$\"3O&GYBGpDf#FE7$Fiz$\"3;C96nD#\\X#FE7$F^[l$\"3gmd>OzlRBF
E7$Fc[l$\"3+<qA\\\\ICAFE7$Fh[l$\"3_Fz\\Vel?@FE7$F]\\l$\"3-D<o2#*3;?FE-
Fb\\l6&Fd\\lF(Fe\\lF(-F$6$7,7$F[]l$\"3%)*************>%F-7$$\"\"\"F)$
\"3y**************GF-7$$\"3++++++++:Fgn$\"3-+++++++AF-7$$\"\"#F)$\"3#*
*************z\"F-7$$\"3++++++++DFgn$\"3%**************\\\"F-7$$\"\"$F
)$\"3+++++++]7F-7$$\"\"%F)$\"3?+++++++'*FE7$$\"\"'F)$\"3y*************
*fFE7$$\"\")F)$\"3#**************z$FE7$F]\\l$\"3/+++++++CFE-Fb\\l6&Fd
\\lFe\\lFe\\lF(-%+AXESLABELSG6$Q\"t6\"Q.ConcentrationFfil-%&TITLEG6#%d
oConcentration~of~Pethidine~vs.~Time~for~k12~=~0.05,~k21~=~0.2,~k10~=~
0.35G-%%VIEWG6$;F(F]\\l;F($\"\"&Ff\\l" 1 2 0 1 10 0 2 9 1 4 2 
1.000000 45.000000 45.000000 0 1 "Conc. of Pethidine in Other Organs" 
"Conc. of Pethidine in Blood Plasma" "Clinical Data for Conc. in Blood
 Plasma" }}}}{EXCHG {PARA 0 "> " 0 "" {MPLTEXT 1 0 155 "plot(\{rhs(sub
n2), rhs(subn1)\}, t = 40..50, Concentration = 0..0.0001, title = `Con
centration of Pethidine vs. Time for k12 = 0.05, k21 = 0.2, k10 = 0.35
`);" }}{PARA 13 "" 1 "" {GLPLOT2D 886 592 592 {PLOTDATA 2 "6'-%'CURVES
G6$7S7$$\"#S\"\"!$\"3sY2DE2_a:!#@7$$\"3Rmm;arz@S!#;$\"3>aq&3)oq,:F-7$$
\"35L$e9ui2/%F1$\"35GG_sd@d9F-7$$\"3omm\"z_\"4iSF1$\"3*yNajg`(39F-7$$
\"3ummT&phN3%F1$\"3!)Q)Q5y(fh8F-7$$\"3CL$e*=)H\\5%F1$\"3H!*eg[LB;8F-7$
$\"3Xm;z/3uCTF1$\"3CE$R3*f_v7F-7$$\"3;+]7LRDXTF1$\"3roGMS?qM7F-7$$\"3#
om\"zR'ok;%F1$\"3W<GE-d&Q>\"F-7$$\"37+]i5`h(=%F1$\"3u`e,e^[a6F-7$$\"3b
LL$3En$4UF1$\"3[l*)px=M:6F-7$$\"3#pm;/RE&GUF1$\"3wOjwF_'>3\"F-7$$\"3!)
****\\K]4]UF1$\"3_yDq1YeX5F-7$$\"3;++]PAvrUF1$\"3]Uj.^`G55F-7$$\"3=++]
nHi#H%F1$\"3EH@$*p+'Rx*!#A7$$\"3Qm;z*ev:J%F1$\"3'e>R&e'yX[*F_p7$$\"30L
L$347TL%F1$\"3e-E.$H1;:*F_p7$$\"3?LLLjM?`VF1$\"3Y!=[N6(py))F_p7$$\"3)*
**\\7o7TvVF1$\"3_p\"=zch9d)F_p7$$\"3OLLLQ*o]R%F1$\"3^IyqV\")Q3$)F_p7$$
\"32+]7=lj;WF1$\"3KziZ1X.H!)F_p7$$\"3J+]PaR<PWF1$\"3Mgj)o*)e<x(F_p7$$
\"3qLLe9EgeWF1$\"3(p$G.\"*G57vF_p7$$\"35L$eR\"3GyWF1$\"3GY.pycI\"G(F_p
7$$\"3emmT5k]*\\%F1$\"3\\[6HiBISqF_p7$$\"3sm;zRQb@XF1$\"3u<LJ^,T)z'F_p
7$$\"3?+](=>Y2a%F1$\"3om!ROk=Yf'F_p7$$\"3%om;zXu9c%F1$\"3Ca5QgWP\"Q'F_
p7$$\"35+++&y))Ge%F1$\"3i@+C#H6$ohF_p7$$\"3.++DE&QQg%F1$\"3CU+bihvmfF_
p7$$\"3C+]7y%3Ti%F1$\"3'\\'=+1B,ydF_p7$$\"3#)***\\P![hYYF1$\"3Q>+-h5Vv
bF_p7$$\"3iLLLQx$om%F1$\"3wE,h8$o%*R&F_p7$$\"3C++]P+V)o%F1$\"3'>\\tlL;
x@&F_p7$$\"3im;zpe*zq%F1$\"3wB()\\i7Je]F_p7$$\"37++]#\\'QHZF1$\"37QB-j
kg*)[F_p7$$\"3cL$e9S8&\\ZF1$\"3w,tH?'4gt%F_p7$$\"3#)**\\i?=bqZF1$\"3-%
RXr\"=h!e%F_p7$$\"3-LL$3s?6z%F1$\"3O\\_`SFhLWF_p7$$\"3y**\\7`Wl7[F1$\"
3Ep))H+.x%G%F_p7$$\"3%pmmm*RRL[F1$\"3yC4`(4Vh9%F_p7$$\"3)pm;a<.Y&[F1$
\"3!*p5ImT,4SF_p7$$\"3kL$e9tOc([F1$\"3oZ'fSL+v(QF_p7$$\"35+++&Qk\\*[F1
$\"3=a()pd(f/w$F_p7$$\"3mLL3dg6<\\F1$\"3n\"R^$>klIOF_p7$$\"3hmmmw(Gp$
\\F1$\"3$e8aVHf$=NF_p7$$\"3')**\\7oK0e\\F1$\"3(42I)Q/X-MF_p7$$\"3I+](=
5s#y\\F1$\"3mzs*G,*3&H$F_p7$$\"#]F*$\"3'QWVl!z[$=$F_p-%'COLOURG6&%$RGB
G$\"#5!\"\"$F*F*Fa[l-F$6$7S7$F($\"3%eiA#fW\"zG\"F-7$F/$\"3uW\\(>>_TC\"
F-7$F5$\"3<PTcAnG27F-7$F:$\"3'yF1UHJr;\"F-7$F?$\"3TN\"=:ve!G6F-7$FD$\"
3s&e?[%4Z!4\"F-7$FI$\"3c'H%H5Auc5F-7$FN$\"3%[ni_=<H-\"F-7$FS$\"3]&Q*oy
\"R2*)*F_p7$FX$\"3!e/w!Rq`k&*F_p7$Fgn$\"3_Ax=k0AS#*F_p7$F\\o$\"3m>'pJ!
[oj*)F_p7$Fao$\"3'Q2+mKiAm)F_p7$Ffo$\"3'=g*zv7!)p$)F_p7$F[p$\"35\\c\\m
&3t4)F_p7$Fap$\"3]yo#e[`v&yF_p7$Ffp$\"33\"p:-Y%o\"e(F_p7$F[q$\"35!ofhC
zbN(F_p7$F`q$\"3W>9k3f.,rF_p7$Feq$\"3ULU(*Q<3$)oF_p7$Fjq$\"3!4p;'o0k^m
F_p7$F_r$\"3<Gqc*o\"\\QkF_p7$Fdr$\"3&f<z$[:PBiF_p7$Fir$\"3#zZaS3h@.'F_
p7$F^s$\"3NyRUwd\\KeF_p7$Fcs$\"34-zzLZ4KcF_p7$Fhs$\"3Q9WE+'fKY&F_p7$F]
t$\"3/>\"3*4Pf'G&F_p7$Fbt$\"3jCg7$Gy+6&F_p7$Fgt$\"3Pu*=GJ(4V\\F_p7$F\\
u$\"3!QP%>#RIny%F_p7$Fau$\"3\"3X]t8+*=YF_p7$Ffu$\"3Q_Z]XD7tWF_p7$F[v$
\"3A*z:!Q\"\\DK%F_p7$F`v$\"37TO=)R*[!>%F_p7$Fev$\"3?Db`=bs]SF_p7$Fjv$
\"3)fI<63yM#RF_p7$F_w$\"3)\\DL]%)QZz$F_p7$Fdw$\"3yA&e\"=x&Hn$F_p7$Fiw$
\"3C')RaT'\\'\\NF_p7$F^x$\"3!)[7:3X![V$F_p7$Fcx$\"3#HfQ'f2?@LF_p7$Fhx$
\"3XfVNX*[A@$F_p7$F]y$\"3!Q***z<vG:JF_p7$Fby$\"3]rj^()Hv2IF_p7$Fgy$\"3
)p)3rM9s9HF_p7$F\\z$\"3.r&Hp'yp=GF_p7$Faz$\"3[s]u9avHFF_p7$Ffz$\"39rfW
B2IPEF_p-F[[l6&F][lFa[lF^[lFa[l-%+AXESLABELSG6$Q\"t6\"Q.ConcentrationF
^el-%&TITLEG6#%doConcentration~of~Pethidine~vs.~Time~for~k12~=~0.05,~k
21~=~0.2,~k10~=~0.35G-%%VIEWG6$;F(Ffz;Fa[l$\"\"\"!\"%" 1 2 0 1 10 0 2 
9 1 4 2 1.000000 47.000000 47.000000 0 1 "Conc. of Pethidine in Other \+
Organs" "Conc. of Pethidine in Blood Plasma" }}}}{EXCHG {PARA 0 "" 0 "
" {TEXT -1 164 "We proceed to demonstrate how the solution behaves in \+
comparison to the clinical data for different set of absorption rates \+
(k12, k21, and k10) and for values of t." }}{PARA 0 "" 0 "" {TEXT -1 
0 "" }}}{EXCHG {PARA 0 "" 0 "" {TEXT -1 38 "For cases where k21 & k12 \+
are similar." }}{PARA 0 "> " 0 "" {MPLTEXT 1 0 74 "subn_value_1 := sim
plify(subs(\{k12 = 0.1, k21 = 0.11, k10 = 0.3\}, solx1));" }}{PARA 0 "
> " 0 "" {MPLTEXT 1 0 75 "subn_value_1_2 := simplify(subs(\{k12 =0.1, \+
k21 = 0.11, k10 = 0.3\}, solx2));" }}{PARA 0 "> " 0 "" {MPLTEXT 1 0 
29 "unassign('k12','k21', 'k10');" }}{PARA 11 "" 1 "" {XPPMATH 20 "6#>
%-subn_value_1G/-%#x1G6#%\"tG,&-%$expG6#,$F)$!+I)pWg(!#6$\"+!4XNu%F1*&
$\"+!\\Xc_%!#5\"\"\"-F,6#,$F)$!+<IbRVF7F8F8" }}{PARA 11 "" 1 "" 
{XPPMATH 20 "6#>%/subn_value_1_2G/-%#x2G6#%\"tG,&-%$expG6#,$F)$!+I)pWg
(!#6$\"+!*o*pR\"!#5*&$\"+!*o*pR\"F4\"\"\"-F,6#,$F)$!+<IbRVF4F8!\"\"" }
}}{EXCHG {PARA 0 "> " 0 "" {MPLTEXT 1 0 177 "plot(\{clinical_data, rhs
(subn_value_1), rhs(subn_value_1_2)\}, t=0..10, Concentration=0..0.5, \+
title = `Concentration of Pethidine vs. Time for k12 = 0.1, k21 = 0.11
, k10 = 0.3`);" }}{PARA 0 "" 0 "" {TEXT -1 0 "" }}{PARA 0 "" 0 "" 
{TEXT -1 0 "" }}{PARA 13 "" 1 "" {GLPLOT2D 963 588 588 {PLOTDATA 2 "6(
-%'CURVESG6$7S7$$\"\"!F)$\"3#*******)*******\\!#=7$$\"3emmm;arz@F,$\"3
W$zX0AWPe%F,7$$\"3[LL$e9ui2%F,$\"3uny&eez<D%F,7$$\"3nmmm\"z_\"4iF,$\"3
V)=u]uk\"4RF,7$$\"39ommT&phN)F,$\"3Qjr\"z^AVf$F,7$$\"3KLLe*=)H\\5!#<$
\"3u1ri&)3E3LF,7$$\"3smm\"z/3uC\"FD$\"376*)zs3ElIF,7$$\"3!****\\7LRDX
\"FD$\"3,<MZ7wDMGF,7$$\"3%om;zR'ok;FD$\"3*)>k31)Rbh#F,7$$\"33++D1J:w=F
D$\"31YiLuE=;CF,7$$\"3oLLL3En$4#FD$\"3aG`\"e1V)GAF,7$$\"3#pmmT!RE&G#FD
$\"3%*)fF2[\\u2#F,7$$\"3D+++D.&4]#FD$\"3w>1f9O'4#>F,7$$\"3;+++vB_<FFD$
\"3K\"\\l=1Dux\"F,7$$\"33+++v'Hi#HFD$\"3-,4T\\+&3l\"F,7$$\"3&om;z*ev:J
FD$\"3E\\;\\&*\\0X:F,7$$\"3_LLL347TLFD$\"3uH=!fl;'H9F,7$$\"3nLLLLY.KNF
D$\"3Y!z&oP(**)R8F,7$$\"33++D\"o7Tv$FD$\"3uZP2\\5/W7F,7$$\"3?LLL$Q*o]R
FD$\"3k:u`X@=m6F,7$$\"3m++D\"=lj;%FD$\"3yXzoCql(3\"F,7$$\"3S++vV&R<P%F
D$\"3<6eFyX->5F,7$$\"3CML$e9Ege%FD$\"3esb!=@oC`*!#>7$$\"3]LLeR\"3Gy%FD
$\"3)Q$HO&opk(*)Ffr7$$\"3emm;/T1&*\\FD$\"3LC&>hkJRU)Ffr7$$\"3=nm\"zRQb
@&FD$\"3;Z<RSES(*yFfr7$$\"3:++v=>Y2aFD$\"3;aIp\"eN]Z(Ffr7$$\"3Znm;zXu9
cFD$\"33IdY2!4L0(Ffr7$$\"34+++]y))GeFD$\"3?lqDyj0_mFfr7$$\"3H++]i_QQgF
D$\"3-$*[X&[u/H'Ffr7$$\"3b++D\"y%3TiFD$\"3Y#y-'[HInfFfr7$$\"3+++]P![hY
'FD$\"3:<p2*3qlj&Ffr7$$\"3iKLL$Qx$omFD$\"3a'Q*zpSYi`Ffr7$$\"3Y+++v.I%)
oFD$\"3og+1fu\"=4&Ffr7$$\"3?mm\"zpe*zqFD$\"3as\"3&\\&)ek[Ffr7$$\"3;,++
D\\'QH(FD$\"3L>i//I7MYFfr7$$\"3%HL$e9S8&\\(FD$\"3$4K;<X(*HV%Ffr7$$\"3s
++D1#=bq(FD$\"3la>'\\t)pPUFfr7$$\"3\"HLL$3s?6zFD$\"3#3bJU>..1%Ffr7$$\"
3a***\\7`Wl7)FD$\"3!e4;'eCt()QFfr7$$\"3enmmm*RRL)FD$\"3xfa!\\.\"=LPFfr
7$$\"3%zmmTvJga)FD$\"31$=uFTmfe$Ffr7$$\"3]MLe9tOc()FD$\"3q_:%[q'*)\\MF
fr7$$\"31,++]Qk\\*)FD$\"34b<>6L(GL$Ffr7$$\"3![LL3dg6<*FD$\"3V\"G6j'pT2
KFfr7$$\"3%ymmmw(Gp$*FD$\"3!\\JWw^BC5$Ffr7$$\"3C++D\"oK0e*FD$\"35\"p[#
e:P(*HFfr7$$\"35,+v=5s#y*FD$\"3KH?fJ7'H!HFfr7$$\"#5F)$\"3T?\"\\LCcw!GF
fr-%'COLOURG6&%$RGBG$Ffz!\"\"F(F(-F$6$7,7$$\"3++++++++]F,$\"3%)*******
******>%F,7$$\"\"\"F)$\"3y**************GF,7$$\"3++++++++:FD$\"3-+++++
++AF,7$$\"\"#F)$\"3#**************z\"F,7$$\"3++++++++DFD$\"3%*********
*****\\\"F,7$$\"\"$F)$\"3+++++++]7F,7$$\"\"%F)$\"3?+++++++'*Ffr7$$\"\"
'F)$\"3y**************fFfr7$$\"\")F)$\"3#**************z$Ffr7$Fez$\"3/
+++++++CFfr-Fjz6&F\\[lF(F][lF(-F$6$7W7$F(F(7$$\"3GLLL3x&)*3\"F,$\"38F'
ztRm-I&!#?7$F.$\"3d.(erk%>J5Ffr7$$\"3v***\\7y%*z7$F,$\"3i!R*)\\zY[W\"F
fr7$F3$\"3>?&=gH^&Q=Ffr7$$\"3z***\\(oMrU^F,$\"3wPc(*G4^eAFfr7$F8$\"3)o
a!y)o9al#Ffr7$$\"3Unmmm6m#G(F,$\"3Zh,**)H_F.$Ffr7$F=$\"3_#oR76k))Q$Ffr
7$FB$\"3Oy6sB\"R%QSFfr7$FH$\"3=K6MlXYvXFfr7$FM$\"3a6hxVFEr]Ffr7$FR$\"3
QpM\"\\TV__&Ffr7$FW$\"3Twy#RS#pBfFfr7$Ffn$\"3?nN;%*eW#G'Ffr7$F[o$\"3?:
-![5$RflFfr7$F`o$\"36^*QJK49$oFfr7$Feo$\"3GF(y<$o/mqFfr7$Fjo$\"3#oCaoG
7\"fsFfr7$F_p$\"3,$=/x(e*)3uFfr7$Fdp$\"33K!=*))fIevFfr7$Fip$\"3c'Q)4hX
qiwFfr7$F^q$\"3Ee7)4oA5w(Ffr7$Fcq$\"3,9D&G?H#HyFfr7$Fhq$\"3eW'Rz+0d)yF
fr7$F]r$\"3$zDzTpNL#zFfr7$Fbr$\"3/nM:38ZZzFfr7$Fhr$\"3%[YXgI_t&zFfr7$F
]s$\"3WT%=zCQh&zFfr7$Fbs$\"3C]y)HAcJ%zFfr7$Fgs$\"3\"oGnG%p7BzFfr7$F\\t
$\"3G^Kc#35L*yFfr7$Fat$\"31k-@J]]ayFfr7$Fft$\"3qc)*3hh_4yFfr7$F[u$\"3-
3WYW!G,w(Ffr7$F`u$\"3MR#)e8\"z#*p(Ffr7$Feu$\"3.PS989%)RwFfr7$Fju$\"3+V
1lJv+svFfr7$F_v$\"3ok-nK&3r](Ffr7$Fdv$\"3-zW\"e9&*GV(Ffr7$Fiv$\"3k\"\\
b3Ua.O(Ffr7$F^w$\"3_dl#QV.@G(Ffr7$Fcw$\"32l4C=Pa.sFfr7$Fhw$\"3\"pj&HNu
X>rFfr7$F]x$\"3nwSrsT)p.(Ffr7$Fbx$\"3qb;'Gw/9&pFfr7$Fgx$\"3#3En[QSb'oF
fr7$F\\y$\"35)*z$4xcfy'Ffr7$Fay$\"37;0PKZ9%p'Ffr7$Ffy$\"3XUxNOyk6mFfr7
$F[z$\"38'eYOC`M_'Ffr7$F`z$\"3I%QT,*e%*QkFfr7$Fez$\"3!3vv'4X;[jFfr-Fjz
6&F\\[lF][lF][lF(-%+AXESLABELSG6$Q\"t6\"Q.ConcentrationFcil-%&TITLEG6#
%coConcentration~of~Pethidine~vs.~Time~for~k12~=~0.1,~k21~=~0.11,~k10~
=~0.3G-%%VIEWG6$;F(Fez;F($\"\"&F^[l" 1 2 0 1 10 0 2 9 1 4 2 1.000000 
45.000000 45.000000 0 1 "Conc. of Pethidine in Blood Plasma" "Clinical
 Data for Conc. of Pethidine in Blood Plasma" "Conc. of Pethidine in O
ther Organs" }}}}{EXCHG {PARA 0 "> " 0 "" {MPLTEXT 1 0 179 "plot(\{cli
nical_data, rhs(subn_value_1), rhs(subn_value_1_2)\}, t=40..50, Concen
tration=0..0.01, title = `Concentration of Pethidine vs. Time for k12 \+
= 0.1, k21 = 0.11, k10 = 0.3`);" }}{PARA 13 "" 1 "" {GLPLOT2D 916 589 
589 {PLOTDATA 2 "6(-%'CURVESG6$7S7$$\"#S\"\"!$\"3?\"*QVH$H]E#!#?7$$\"3
Rmm;arz@S!#;$\"3)3;EQj$zFAF-7$$\"35L$e9ui2/%F1$\"33Xv!p[$*e>#F-7$$\"3o
mm\"z_\"4iSF1$\"3!3fGY(Qcg@F-7$$\"3ummT&phN3%F1$\"3^+jl#>ub7#F-7$$\"3C
L$e*=)H\\5%F1$\"3iRJj\"\\884#F-7$$\"3Xm;z/3uCTF1$\"31!pq<+V+1#F-7$$\"3
;+]7LRDXTF1$\"3d?cP)*o:G?F-7$$\"3#om\"zR'ok;%F1$\"3?Sg'\\M*p&*>F-7$$\"
37+]i5`h(=%F1$\"3Y%*ojlG'Q'>F-7$$\"3bLL$3En$4UF1$\"3\"[)3is\\kJ>F-7$$
\"3#pm;/RE&GUF1$\"3K.SZXbq.>F-7$$\"3!)****\\K]4]UF1$\"3[&3N'[cts=F-7$$
\"3;++]PAvrUF1$\"3t=GgLb9U=F-7$$\"3=++]nHi#H%F1$\"3I!p2,>RJ\"=F-7$$\"3
Qm;z*ev:J%F1$\"3_KYleX>(y\"F-7$$\"30LL$347TL%F1$\"3!p0vIlEov\"F-7$$\"3
?LLLjM?`VF1$\"3S\"R;n80:t\"F-7$$\"3)***\\7o7TvVF1$\"3*f.g%R!4Dq\"F-7$$
\"3OLLLQ*o]R%F1$\"3]f$z;*zCx;F-7$$\"32+]7=lj;WF1$\"3'*G_,HO'*\\;F-7$$
\"3J+]PaR<PWF1$\"3*)zIbL^RC;F-7$$\"3qLLe9EgeWF1$\"3)4*zg!RR\")f\"F-7$$
\"35L$eR\"3GyWF1$\"3_KlZ%R-Wd\"F-7$$\"3emmT5k]*\\%F1$\"31(Qb3$R>\\:F-7
$$\"3sm;zRQb@XF1$\"3j!GN1rOM_\"F-7$$\"3?+](=>Y2a%F1$\"3Zdp)Q)QO,:F-7$$
\"3%om;zXu9c%F1$\"3QW$*\\<P)yZ\"F-7$$\"35+++&y))Ge%F1$\"3gI]R\"*>,a9F-
7$$\"3.++DE&QQg%F1$\"3qipD[8.J9F-7$$\"3C+]7y%3Ti%F1$\"3hSON!=U\"49F-7$
$\"3#)***\\P![hYYF1$\"3Il<-U+B&Q\"F-7$$\"3iLLLQx$om%F1$\"39qrmM-4k8F-7
$$\"3C++]P+V)o%F1$\"34rr=y\\(=M\"F-7$$\"3im;zpe*zq%F1$\"3&Qe:5Fd?K\"F-
7$$\"37++]#\\'QHZF1$\"3ElGjIgs+8F-7$$\"3cL$e9S8&\\ZF1$\"3_5Q#oPp4G\"F-
7$$\"3#)**\\i?=bqZF1$\"3;UVi&oQ1E\"F-7$$\"3-LL$3s?6z%F1$\"30\\p/7P2T7F
-7$$\"3y**\\7`Wl7[F1$\"3nu)3iE;4A\"F-7$$\"3%pmmm*RRL[F1$\"3\"oI()3#=\"
=?\"F-7$$\"3)pm;a<.Y&[F1$\"3G1qV,Re#=\"F-7$$\"3kL$e9tOc([F1$\"3gp!*GL!
>Q;\"F-7$$\"35+++&Qk\\*[F1$\"3Adr_$pQo9\"F-7$$\"3mLL3dg6<\\F1$\"3vykh
\"y\"oF6F-7$$\"3hmmmw(Gp$\\F1$\"3]*zkL()=36\"F-7$$\"3')**\\7oK0e\\F1$
\"3K#=&3ir6$4\"F-7$$\"3I+](=5s#y\\F1$\"33\\RPN'Qk2\"F-7$$\"#]F*$\"39p*
z%\\))ze5F--%'COLOURG6&%$RGBG$\"#5!\"\"$F*F*F`[l-F$6$7,7$$\"3++++++++]
!#=$\"3%)*************>%Fg[l7$$\"\"\"F*$\"3y**************GFg[l7$$\"3+
+++++++:!#<$\"3-+++++++AFg[l7$$\"\"#F*$\"3#**************z\"Fg[l7$$\"3
++++++++DFb\\l$\"3%**************\\\"Fg[l7$$\"\"$F*$\"3+++++++]7Fg[l7$
$\"\"%F*$\"3?+++++++'*!#>7$$\"\"'F*$\"3y**************fFi]l7$$\"\")F*$
\"3#**************z$Fi]l7$$F^[lF*$\"3/+++++++CFi]l-Fjz6&F\\[lF`[lF][lF
`[l-F$6$7S7$F($\"3U*zA#GzdqmF-7$F/$\"3e<,jb3#4c'F-7$F5$\"39/@,[k(pY'F-
7$F:$\"31B_8$>KHO'F-7$F?$\"3C\"[$f)y)))fiF-7$FD$\"3kagb)*>**ehF-7$FI$
\"3Ih/)\\7,p1'F-7$FN$\"3cvGsDr*H(fF-7$FS$\"3?z:%=15u(eF-7$FX$\"3#Rz3+
\">l$y&F-7$Fgn$\"3[!*Hfi.x)o&F-7$F\\o$\"3&ebsLx)[1cF-7$Fao$\"34lg#oM#G
:bF-7$Ffo$\"3D'3d[F%>DaF-7$F[p$\"3(=>4)H.xR`F-7$F`p$\"31R2o%3jLE&F-7$F
ep$\"3Ej@9m\"HR<&F-7$Fjp$\"3GI[&[(oN*4&F-7$F_q$\"3Z)>4j\"G'R,&F-7$Fdq$
\"3xZyP'\\o&R\\F-7$Fiq$\"3#e<'))=a@f[F-7$F^r$\"3e#GXKc:Ry%F-7$Fcr$\"3)
R\"\\T-<f1ZF-7$Fhr$\"3)f?$[\"e&oOYF-7$F]s$\"3S)Q><\"fWiXF-7$Fbs$\"3[6i
v,,f'[%F-7$Fgs$\"3ju=L<\\e@WF-7$F\\t$\"3c4oYY]V_VF-7$Fat$\"3!Gj<L*>8#G
%F-7$Fft$\"3(3&p&o=`W@%F-7$F[u$\"3y,\\b$z))*\\TF-7$F`u$\"3W:g(zlm&zSF-
7$Feu$\"3)\\P))G74t,%F-7$Fju$\"3A^*=HL%)=&RF-7$F_v$\"3A>310/_$*QF-7$Fd
v$\"3-8e,\\!*pIQF-7$Fiv$\"3-$f(z,\\^sPF-7$F^w$\"3$**)==!=SEr$F-7$Fcw$
\"3Gu0_=0-bOF-7$Fhw$\"3qAuy\"*fl&f$F-7$F]x$\"3GO^V(e#RRNF-7$Fbx$\"3c,A
nQbw#[$F-7$Fgx$\"3>q8t)=-vU$F-7$F\\y$\"3yoxZYV\\xLF-7$Fay$\"3:%R'*zRw5
K$F-7$Ffy$\"3a>c5'Q99F$F-7$F[z$\"3_0OFd?G>KF-7$F`z$\"3Mj`I[I;qJF-7$Fez
$\"3x$4kO38#=JF--Fjz6&F\\[lF][lF][lF`[l-%+AXESLABELSG6$Q\"t6\"Q.Concen
trationFfhl-%&TITLEG6#%coConcentration~of~Pethidine~vs.~Time~for~k12~=
~0.1,~k21~=~0.11,~k10~=~0.3G-%%VIEWG6$;F(Fez;F`[l$F\\\\l!\"#" 1 2 0 1 
10 0 2 9 1 4 2 1.000000 45.000000 45.000000 0 1 "Conc. of Pethidine in
 Blood Plasma" "Conc. of Pethidine in Other Organs" "Conc. of Pethidin
e in Other Organs" }}}}{EXCHG {PARA 0 "" 0 "" {TEXT 256 39 "For cases \+
where k21 and k10 are similar" }}{PARA 0 "" 0 "" {TEXT -1 0 "" }}
{PARA 0 "> " 0 "" {MPLTEXT 1 0 75 "subn_value_2 := simplify(subs(\{k12
 = 0.1, k21 = 0.29, k10 = 0.30\}, solx1));" }}{PARA 0 "> " 0 "" 
{MPLTEXT 1 0 77 "subn_value_2_2 := simplify(subs(\{k12 = 0.1, k21 = 0.
29, k10 = 0.30\}, solx2));" }}{PARA 0 "> " 0 "" {MPLTEXT 1 0 29 "unass
ign('k12','k21', 'k10');" }}{PARA 11 "" 1 "" {XPPMATH 20 "6#>%-subn_va
lue_2G/-%#x1G6#%\"tG,&-%$expG6#,$F)$!+$)pWg;!#5$\"+5<lJ<F1*&$\"+*G[$oK
F1\"\"\"-F,6#,$F)$!+:IbR_F1F7F7" }}{PARA 11 "" 1 "" {XPPMATH 20 "6#>%/
subn_value_2_2G/-%#x2G6#%\"tG,&-%$expG6#,$F)$!+$)pWg;!#5$\"+!*o*pR\"F1
*&$\"+!*o*pR\"F1\"\"\"-F,6#,$F)$!+:IbR_F1F7!\"\"" }}}{EXCHG {PARA 0 ">
 " 0 "" {MPLTEXT 1 0 172 "plot(\{rhs(subn_value_2), rhs(subn_value_2_2
), clinical_data\}, t=0..10, Concentration = 0..0.5, title = `Conc. of
 Pethidine vs. Time for k12 = 0.1, k21 = 0.29, k10 = 0.30`);" }}{PARA 
0 "> " 0 "" {MPLTEXT 1 0 0 "" }}{PARA 13 "" 1 "" {GLPLOT2D 941 597 
597 {PLOTDATA 2 "6(-%'CURVESG6$7X7$$\"\"!F)F(7$$\"3GLLL3x&)*3\"!#=$\"3
%y*344<`[_!#?7$$\"3emmm;arz@F-$\"3V1Q3#Qi6,\"!#>7$$\"3v***\\7y%*z7$F-$
\"3t*=()RuQZS\"F67$$\"3[LL$e9ui2%F-$\"3k<s%4gBBx\"F67$$\"3z***\\(oMrU^
F-$\"3Yk,d1$fj:#F67$$\"3nmmm\"z_\"4iF-$\"3d$*zteQ46DF67$$\"3Unmmm6m#G(
F-$\"3)*o:Wt![.%GF67$$\"39ommT&phN)F-$\"3*y1$\\(\\]L9$F67$$\"3A,+v=ddC
%*F-$\"3&H*)pwp:/U$F67$$\"3KLLe*=)H\\5!#<$\"3SNOc.g^uOF67$$\"3smm\"z/3
uC\"Fgn$\"3e=1;$)od*3%F67$$\"3!****\\7LRDX\"Fgn$\"3i,+w(f4)\\WF67$$\"3
%om;zR'ok;Fgn$\"3S`v>>(okv%F67$$\"33++D1J:w=Fgn$\"3D,I_6DM.]F67$$\"3oL
LL3En$4#Fgn$\"3\"y!=M*H'[._F67$$\"3#pmmT!RE&G#Fgn$\"3va#*H[H**R`F67$$
\"3D+++D.&4]#Fgn$\"3c`kF)fCXX&F67$$\"3;+++vB_<FFgn$\"3'H74[zmH`&F67$$
\"33+++v'Hi#HFgn$\"3A(>Z@Vr$ybF67$$\"3&om;z*ev:JFgn$\"3K_l#3w#=(f&F67$
$\"3_LLL347TLFgn$\"3_SUm)p2af&F67$$\"3nLLLLY.KNFgn$\"3/)Ru?\"p0wbF67$$
\"33++D\"o7Tv$Fgn$\"32@\\fMO%e`&F67$$\"3?LLL$Q*o]RFgn$\"3'4-7r.jl[&F67
$$\"3m++D\"=lj;%Fgn$\"3B-jVmv!*>aF67$$\"3S++vV&R<P%Fgn$\"3_\"[,/.QgM&F
67$$\"3CML$e9Ege%Fgn$\"31\\\"p(Gq*)f_F67$$\"3]LLeR\"3Gy%Fgn$\"3-A>:\"3
()R<&F67$$\"3emm;/T1&*\\Fgn$\"3'[P(GK=Jv]F67$$\"3=nm\"zRQb@&Fgn$\"3#Q!
fj9zZn\\F67$$\"3:++v=>Y2aFgn$\"3'))Q2W^*4q[F67$$\"3Znm;zXu9cFgn$\"3iJ&
pP7*4iZF67$$\"34+++]y))GeFgn$\"3_wS4TRB[YF67$$\"3H++]i_QQgFgn$\"3)*3%G
0n#HNXF67$$\"3b++D\"y%3TiFgn$\"3VKBR[o8DWF67$$\"3+++]P![hY'Fgn$\"3=PB+
/;S-VF67$$\"3iKLL$Qx$omFgn$\"3;7R+n$)=#>%F67$$\"3Y+++v.I%)oFgn$\"3KhmM
B=+vSF67$$\"3?mm\"zpe*zqFgn$\"3YC^Zy`bpRF67$$\"3;,++D\\'QH(Fgn$\"3c5oO
nBPbQF67$$\"3%HL$e9S8&\\(Fgn$\"3%y:wpF8#\\PF67$$\"3s++D1#=bq(Fgn$\"35v
:<W&z(ROF67$$\"3\"HLL$3s?6zFgn$\"3\")*\\n%=QZMNF67$$\"3a***\\7`Wl7)Fgn
$\"39bG<h#ohU$F67$$\"3enmmm*RRL)Fgn$\"3d)\\DwZaQK$F67$$\"3%zmmTvJga)Fg
n$\"3;NA(3A^8A$F67$$\"3]MLe9tOc()Fgn$\"3*3cXmp**=7$F67$$\"31,++]Qk\\*)
Fgn$\"3LIaRi**\\KIF67$$\"3![LL3dg6<*Fgn$\"3r432/AUKHF67$$\"3%ymmmw(Gp$
*Fgn$\"3M#e66f'4XGF67$$\"3C++D\"oK0e*Fgn$\"31,K4N'zUv#F67$$\"35,+v=5s#
y*Fgn$\"3W%ecvyw&pEF67$$\"#5F)$\"3+j!GX3r4e#F6-%'COLOURG6&%$RGBG$F^\\l
!\"\"F(F(-F$6$7,7$$\"3++++++++]F-$\"3%)*************>%F-7$$\"\"\"F)$\"
3y**************GF-7$$\"3++++++++:Fgn$\"3-+++++++AF-7$$\"\"#F)$\"3#***
***********z\"F-7$$\"3++++++++DFgn$\"3%**************\\\"F-7$$\"\"$F)$
\"3+++++++]7F-7$$\"\"%F)$\"3?+++++++'*F67$$\"\"'F)$\"3y**************f
F67$$\"\")F)$\"3#**************z$F67$F]\\l$\"3/+++++++CF6-Fb\\l6&Fd\\l
F(Fe\\lF(-F$6$7S7$F($\"3#*******)*******\\F-7$F2$\"3+F#*=(y.de%F-7$F=$
\"3U(G2]\\K\"eUF-7$FG$\"3)>al9],F#RF-7$FQ$\"3e**G&4dDoh$F-7$Fen$\"3q#R
@62W3M$F-7$F[o$\"3u5aEY*4y5$F-7$F`o$\"3i\\?\"=.>u)GF-7$Feo$\"3'p02gT*p
zEF-7$Fjo$\"3mKo=!*p3\"\\#F-7$F_p$\"3L$=P\"\\4P9BF-7$Fdp$\"3iQjGX\"[=<
#F-7$Fip$\"3X(Q%)oi'pC?F-7$F^q$\"3)[b4oDa(*)=F-7$Fcq$\"3+C)))>Rt1x\"F-
7$Fhq$\"3s0iB]e)4n\"F-7$F]r$\"3e=.mE2$>c\"F-7$Fbr$\"3E/)\\b'Q(oZ\"F-7$
Fgr$\"3[i1fl`e&Q\"F-7$F\\s$\"3h!*H!=<F5J\"F-7$Fas$\"38&fIr(pMN7F-7$Ffs
$\"3;w.0E.qo6F-7$F[t$\"3yEFmE2G/6F-7$F`t$\"39'Qt80A$\\5F-7$Fet$\"3xegE
fK]T**F67$Fjt$\"3?tN$>u%f4%*F67$F_u$\"3s8%*yo7wx*)F67$Fdu$\"3\"3<`mv37
a)F67$Fiu$\"3=fu(3*[/?\")F67$F^v$\"3.%HTQD%)[t(F67$Fcv$\"37&3H55>aQ(F6
7$Fhv$\"3-D+\\U$4>-(F67$F]w$\"3!f^-=8*\\:nF67$Fbw$\"3Wr%\\w\"zu2kF67$F
gw$\"3>6&fjKi[9'F67$F\\x$\"3=ksIx3^teF67$Fax$\"3E@M\")[(pBj&F67$Ffx$\"
39P6'*Q1\"RR&F67$F[y$\"3QPAj`_Ct^F67$F`y$\"3qGG>8T[a\\F67$Fey$\"39q_o6
E![v%F67$Fjy$\"3Elztw\"*)4c%F67$F_z$\"3kTI)oMZ%yVF67$Fdz$\"3^aS,n-k=UF
67$Fiz$\"3(*RGb^R@WSF67$F^[l$\"3!*o`D?)3c*QF67$Fc[l$\"3IuCBMwPWPF67$Fh
[l$\"3ADF5ZA=1OF67$F]\\l$\"3yLA3?=QkMF6-Fb\\l6&Fd\\lFe\\lFe\\lF(-%+AXE
SLABELSG6$Q\"t6\"Q.ConcentrationFhil-%&TITLEG6#%\\oConc.~of~Pethidine~
vs.~Time~for~k12~=~0.1,~k21~=~0.29,~k10~=~0.30G-%%VIEWG6$;F(F]\\l;F($
\"\"&Ff\\l" 1 2 0 1 10 0 2 9 1 4 2 1.000000 43.000000 42.000000 0 1 "C
onc. of Pethidine in Other Organs" "Conc. of Pethidine in Blood Plasma
" "Clinical Data for Conc. of Pethidine in Blood Plasma" }}}}{EXCHG 
{PARA 0 "> " 0 "" {MPLTEXT 1 0 264 "plot(\{rhs(subn_value_2), rhs(subn
_value_2_2), [[0.5,.42],[1,0.29],[1.5,0.22],[2,0.18],[2.5,0.15],[3,0.1
25],[4,0.096],[6,0.06],[8,0.038],[10,0.024]]\}, t=40..50, Concentratio
n = 0..0.0003, title = `Conc. of Pethidine vs. Time for k12 = 0.1, k21
 = 0.29, k10 = 0.30`);" }}{PARA 0 "> " 0 "" {MPLTEXT 1 0 0 "" }}{PARA 
13 "" 1 "" {GLPLOT2D 904 571 571 {PLOTDATA 2 "6(-%'CURVESG6$7S7$$\"#S
\"\"!$\"3M[zt)>]E#=!#@7$$\"3Rmm;arz@S!#;$\"3;3`=pD'yv\"F-7$$\"35L$e9ui
2/%F1$\"3mci?DxO.<F-7$$\"3omm\"z_\"4iSF1$\"3g\\mS(>)4W;F-7$$\"3ummT&ph
N3%F1$\"3s%)4=!\\=le\"F-7$$\"3CL$e*=)H\\5%F1$\"3ZWJbjZ@J:F-7$$\"3Xm;z/
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